Pre-Implantation Genetic Testing Basics

The Basics of Preimplantation Genetic Testing

Preimplantation Genetic Testing is an embryonic procedure undertaken alongside IVF to ensure that genetic disorders can be identified and possibly, rectified. For this procedure, a tissue biopsy of a developing embryo is taken and tested for genetic abnormalities. This takes places at the blastocysts stage of the embryos.

Once the tissue sample is collected it is sent for laboratory work, which ascertains the normalcy of the embryo. There are three primary categories of the preimplantation testing which are identified as – preimplantation genetic testing for aneuploidies (PGT-A), preimplantation genetic testing for monogenic/single gene defects (PGT-M), and preimplantation genetic testing for chromosomal structural rearrangements (PGT-SR)

PGT-A PGT-M PGT-SR
Patient Profile All IVF Patients Only high-risk patients with an earlier child suffering from genetic disorders Patients who have a chromosomal rearrangement required.
Objective of the Test Increase chances of successful pregnancy Reduce risk of transmitting genetic disorders Increase chances of successful pregnancy with appropriate chromosomal alignment
Genetic Profile Screening for chromosomal abnormalities Screening for single genetic disorder Screening for specific chromosomal abnormalities
Personalization Not required Yes required Mostly not required.

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